Main objectives are to gene edit human stem cell populations and to direct the differentiation of such cells to generate pancreatic islet and immune cells. With extensive experience in all aspects of gene editing, directed differentiation of human stem cells towards endocrine and T cell lineages, as well as functional analysis of such cells, the core will generate human stem cell derived islet and immune cells with the intent of implementing gene modifications derived from the investigative studies on human T1D samples.
Pancreatic islet cells and Immune cells
- hESC (MEL1-INS-GFP line) and iPSC-derived beta cells
- hPSC-derived beta cells
- ipSC-derived T cells