Project 2

Optimization of islet transplantation

Research Description

The project teams will investigate the use of safer and improved immune conditioning approaches for hematopoietic stem cell transplantation to test the hypothesis that mixed chimerism obtained by using an antibody-based low toxic conditioning together with adoptive transfer of Tregs can be used to achieve durable allogeneic islet transplantation and to cure diabetes.


Seung Kim, Judith Shizuru, Everett Meyer, Qizhi Tang, Jeffrey Bluestone